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Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic

Sang Heon Suh1, Tae Ryom Oh1, Hong Sang Choi1

  • 1Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, Korea.

Nutrients
|October 23, 2021
PubMed

Insights

High body weight variability (BWV) increases cardiovascular risks in pre-dialysis chronic kidney disease (CKD) patients. This variability is linked to higher rates of cardiovascular events and mortality, even without significant weight changes.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Research

Background:

  • Pre-dialysis chronic kidney disease (CKD) patients face elevated cardiovascular (CV) risks.
  • Body weight variability (BWV) is a potential, yet understudied, predictor of adverse outcomes in this population.

Purpose of the Study:

  • To examine the association between body weight variability (BWV) and adverse cardiovascular (CV) outcomes in patients with pre-dialysis CKD.
  • To determine if BWV independently predicts CV events and mortality in this cohort.

Main Methods:

  • Analysis of 1867 participants from the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD).
  • BWV calculated as the average absolute difference between successive weight measurements.
  • Outcomes included a composite of non-fatal CV events and all-cause mortality, as well as fatal/non-fatal CV events and all-cause mortality.

Main Results:

  • High BWV was significantly associated with an increased risk of the composite outcome (aHR 1.745, 95% CI 1.065 to 2.847).
  • Increased risk observed for fatal and non-fatal CV events (aHR 1.845, 95% CI 1.136 to 2.996) and all-cause mortality (aHR 1.861, 95% CI 1.101 to 3.145).
  • High BWV predicted adverse CV events even in patients without significant weight fluctuations (aHR 2.755, 95% CI 1.114 to 6.813).

Conclusions:

  • High body weight variability is an independent risk factor for adverse cardiovascular outcomes in pre-dialysis CKD patients.
  • BWV should be considered in risk stratification and management strategies for CKD patients.
  • Further research into the mechanisms linking BWV and CV events in CKD is warranted.

Keywords:
all-cause mortalitybody weight variabilitycardiovascular eventschronic kidney disease

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