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Metabolic Syndrome and Sarcopenia
Hiroki Nishikawa1,2, Akira Asai1, Shinya Fukunishi1,2
1Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan.
Nutrients
|October 23, 2021
Summary
Metabolic syndrome (Met-S) and sarcopenia (loss of muscle mass) are linked. Their combined presence worsens health outcomes, increasing frailty and mortality risk.
Area of Science:
- Endocrinology
- Gerontology
- Metabolic Health
Background:
- Skeletal muscle is crucial for glucose metabolism and insulin resistance (IR).
- Muscle loss and intramuscular fat accumulation are linked to pathologies like oxidative stress and inflammation.
- Sarcopenia, common in the elderly, involves muscle mass and quality decline.
Purpose of the Study:
- To outline the relationship between metabolic syndrome (Met-S) and sarcopenia.
- To explore the molecular mechanisms and clinical impacts of their association.
- To highlight the increased health risks in patients with both Met-S and sarcopenia.
Main Methods:
- Review of existing literature on Met-S and sarcopenia.
- Analysis of molecular pathways involved in muscle wasting and metabolic dysfunction.
- Examination of clinical data on co-occurrence and health outcomes.
Main Results:
- Met-S and sarcopenia share common underlying factors like inflammation and IR.
- Co-occurrence of Met-S and sarcopenia significantly elevates risks of frailty, dependence, and mortality.
- Met-S can contribute to sarcopenic obesity, further complicating health.
Conclusions:
- Met-S and sarcopenia represent a significant health challenge, particularly in aging populations.
- Understanding their interplay is vital for developing targeted interventions.
- Simultaneous management of Met-S and sarcopenia is crucial for improving quality of life and reducing adverse events.
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