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Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique.
Ezgi Cinan1, Sumeyye Cesur2, Merve Erginer Haskoylu1
1Industrial Biotechnology and System Biology (IBSB) Research Group, Department of Bioengineering, Marmara University, Istanbul 34722, Turkey.
Nanomaterials (Basel, Switzerland)
|October 23, 2021
Summary
Researchers fabricated levan nanoparticles using electrohydrodynamic atomization (EHDA) for drug delivery. These safe, biocompatible nanoparticles show potential for wound healing and tissue engineering applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Nanostructured systems are crucial in biomedical applications.
- There is a growing demand for levan-based nanoparticles as drug delivery vehicles.
Purpose of the Study:
- To fabricate levan nanoparticles using the electrohydrodynamic atomization (EHDA) technique.
- To characterize the levan nanoparticles for biomedical applications.
Main Methods:
- Hydrolyzed Halomonas levan (hHL) was used to create nanoparticles via EHDA.
- EHDA parameters were optimized for nanoparticle fabrication.
- Characterization included morphology, molecular interactions, drug release, and in vitro cell studies.
Main Results:
- Optimized hHL nanoparticles were monodisperse with smooth surfaces (82.06 ± 15.33 nm).
- Resveratrol (RS)-loaded nanoparticles exhibited pH-dependent release, following a first-order model.
- Higher RS loading resulted in a more gradual release profile.
- In vitro biocompatibility assays confirmed safety for human dermal fibroblast cell lines.
Conclusions:
- Fabricated hHL-based nanoparticles are suitable for drug delivery systems.
- Potential applications include wound healing and tissue engineering.
- Coating surfaces with these nanoparticles may enhance cellular interaction.
