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Ionic and Enzymatic Multiple-Crosslinked Nanogels for Drug Delivery
Qian Tao1, Julong Zhong1, Rui Wang1
1School of Chemistry and Materials Science, Ludong University, Yantai 264025, China.
Polymers
|October 23, 2021
Summary
This study developed biocompatible nanogels using ionic and enzymatic crosslinking of chitosan for drug delivery. Optimized nanogels showed high drug loading and release dependent on pH and dosage, primarily driven by diffusion.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Chitosan-based hydrogels are promising for biomedical applications due to their biocompatibility.
- Developing advanced network materials requires efficient crosslinking strategies.
Purpose of the Study:
- To synthesize and characterize multiple-crosslinked chitosan nanogels using both ionic and enzymatic crosslinking methods.
- To evaluate the suitability of these nanogels for drug delivery applications.
Main Methods:
- Chitosan modification followed by dual crosslinking (ionic and enzymatic).
- Nanogel characterization for size, uniformity, drug loading, and encapsulation efficiency.
- In vitro drug release studies under varying pH and drug dosage conditions.
- Analysis of drug release kinetics using established models.
Main Results:
- Preparation methods and ionic crosslinkers effectively controlled nanogel size and uniformity.
- Optimized nanogels achieved high drug-loading content (35.01%) and encapsulation efficiency (66.82%).
- Drug release was pH-dependent, with lower pH and lower drug dosage enhancing release.
- Drug diffusion was identified as the primary mechanism governing drug release.
Conclusions:
- Multiple-crosslinking of chitosan using ionic and enzymatic methods offers a versatile approach for creating biocompatible nanogels.
- These nanogels demonstrate significant potential as effective drug delivery vehicles.
- The findings provide a new perspective for developing advanced biocompatible materials.
