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SEA and GATOR 10 Years Later.
Yahir A Loissell-Baltazar1, Svetlana Dokudovskaya1
1CNRS UMR9018, Institut Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France.
Cells
|October 23, 2021
Summary
The SEA/GATOR complex regulates the mTORC1 pathway. This review details its functions in nutrient response and links GATOR mutations to cancer and neurodegenerative diseases.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The SEA complex was first identified in yeast Saccharomyces cerevisiae, with its human homologue, the GATOR complex, discovered later.
- Over the past decade, significant research has elucidated the biological roles of the SEA/GATOR complex across various organisms.
Purpose of the Study:
- To review the advances in understanding SEA/GATOR complex biology.
- To define its role as an upstream regulator of the mTORC1 pathway.
- To highlight the implications of GATOR mutations in diseases.
Main Methods:
- Literature review of studies on SEA/GATOR complex.
- Analysis of research on mTORC1 pathway regulation.
- Examination of genetic studies linking GATOR mutations to diseases.
Main Results:
- The SEA/GATOR complex is a crucial upstream regulator of the mTORC1 pathway.
- Multiple functions of the SEA/GATOR complex in nutrient response have been identified.
- GATOR mutations are associated with cancer and neurodegenerative diseases.
Conclusions:
- The SEA/GATOR complex plays a vital role in cellular nutrient sensing and metabolic regulation.
- Dysregulation of the GATOR complex has significant implications for human health, particularly in cancer and neurological disorders.
