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Quantifying Renin-Angiotensin-System Alterations in COVID-19

Fabrizio Pucci1,2, Filippo Annoni3, Robson Augusto Souza Dos Santos4

  • 13BIO-Computational Biology and Bioinformatics, Université Libre de Bruxelles, 1050 Brussels, Belgium.

Cells
|October 23, 2021
PubMed

Insights

The renin-angiotensin system (RAS) is altered in COVID-19, impacting inflammation and blood pressure. Research explores RAS drug therapies to mitigate disease severity and understand infection mechanisms.

Area of Science:

  • Physiology
  • Virology
  • Immunology

Background:

  • The renin-angiotensin system (RAS) regulates critical physiological functions, including inflammation and blood pressure.
  • Angiotensin-converting enzyme 2 (ACE2) is identified as the SARS-CoV-2 entry receptor, linking RAS to COVID-19 pathogenesis.
  • SARS-CoV-2 infection causes significant dysregulation of the RAS, prompting extensive research.

Purpose of the Study:

  • To analyze alterations in RAS regulatory axes caused by SARS-CoV-2 infection.
  • To investigate the link between impaired RAS functioning and COVID-19 pathophysiology through meta-analysis.
  • To review potential therapeutic strategies involving RAS-targeting drugs for COVID-19.

Main Methods:

  • Comprehensive meta-analysis of clinical investigations and experimental data on RAS components in COVID-19.
  • Quantification of RAS component levels and activity.
  • Review of existing literature on RAS-targeting drugs and their effects.

Main Results:

  • SARS-CoV-2 infection leads to significant alterations in RAS regulatory axes.
  • Meta-analysis reveals links between impaired RAS functioning and COVID-19 characteristics.
  • Evidence suggests potential benefits of RAS-targeting drugs in managing COVID-19 severity.

Conclusions:

  • Understanding RAS dysregulation in COVID-19 is crucial for developing effective treatments.
  • Further research is needed to resolve conflicting evidence and clarify open questions regarding RAS in SARS-CoV-2 infection.
  • Targeting the RAS may offer a therapeutic avenue to restore normal function and reduce COVID-19 severity.
Keywords:
ACE2Angiotensin IIAngiotensin-(1-7)RAS dysregulationRAS-targeting drugsSARS-CoV-2spike protein

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