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Quantifying Renin-Angiotensin-System Alterations in COVID-19
Fabrizio Pucci1,2, Filippo Annoni3, Robson Augusto Souza Dos Santos4
13BIO-Computational Biology and Bioinformatics, Université Libre de Bruxelles, 1050 Brussels, Belgium.
Cells
|October 23, 2021
Summary
The renin-angiotensin system (RAS) is altered in COVID-19, impacting inflammation and blood pressure. Research explores RAS drug therapies to mitigate disease severity and understand infection mechanisms.
Area of Science:
- Physiology
- Virology
- Immunology
Background:
- The renin-angiotensin system (RAS) regulates critical physiological functions, including inflammation and blood pressure.
- Angiotensin-converting enzyme 2 (ACE2) is identified as the SARS-CoV-2 entry receptor, linking RAS to COVID-19 pathogenesis.
- SARS-CoV-2 infection causes significant dysregulation of the RAS, prompting extensive research.
Purpose of the Study:
- To analyze alterations in RAS regulatory axes caused by SARS-CoV-2 infection.
- To investigate the link between impaired RAS functioning and COVID-19 pathophysiology through meta-analysis.
- To review potential therapeutic strategies involving RAS-targeting drugs for COVID-19.
Main Methods:
- Comprehensive meta-analysis of clinical investigations and experimental data on RAS components in COVID-19.
- Quantification of RAS component levels and activity.
- Review of existing literature on RAS-targeting drugs and their effects.
Main Results:
- SARS-CoV-2 infection leads to significant alterations in RAS regulatory axes.
- Meta-analysis reveals links between impaired RAS functioning and COVID-19 characteristics.
- Evidence suggests potential benefits of RAS-targeting drugs in managing COVID-19 severity.
Conclusions:
- Understanding RAS dysregulation in COVID-19 is crucial for developing effective treatments.
- Further research is needed to resolve conflicting evidence and clarify open questions regarding RAS in SARS-CoV-2 infection.
- Targeting the RAS may offer a therapeutic avenue to restore normal function and reduce COVID-19 severity.
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