Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

13.2K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
13.2K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

22.7K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
22.7K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.6K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.6K
Polymers02:34

Polymers

38.1K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
38.1K
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

6.3K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
6.3K
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

2.1K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase space geometry of isolated to condensed chemical reactions.

The Journal of chemical physics·2021
Same author

Engineered nanoparticle network models for autonomous computing.

The Journal of chemical physics·2021
Same author

Influence of external driving on decays in the geometry of the LiCN isomerization.

The Journal of chemical physics·2020
Same author

Optimizing bags of artificial neural networks for the prediction of viability from sparse data.

The Journal of chemical physics·2020
Same author

Phase-space resolved rates in driven multidimensional chemical reactions.

The Journal of chemical physics·2020
Same author

Transition state theory for activated systems with driven anharmonic barriers.

The Journal of chemical physics·2017

Related Experiment Video

Updated: Oct 15, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.5K

Building blocks for autonomous computing materials: Dimers, trimers, and tetramers.

Xingfei Wei1, Yinong Zhao2, Yi Zhuang1

  • 1Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.

The Journal of Chemical Physics
|October 23, 2021
PubMed
Summary

Stable nanoparticle networks mimicking neuronal connections were created using gold nanoparticles and polymer linkers. These assemblies show promise for brain-like computing, with potential for advanced data storage and processing applications.

More Related Videos

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.8K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.1K

Related Experiment Videos

Last Updated: Oct 15, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.5K
Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.8K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.1K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Computational Chemistry

Background:

  • Autonomous computing materials are key for next-generation devices.
  • Nanoparticle networks show potential for brain-like computing.

Purpose of the Study:

  • To investigate the stability of polymer-networked gold nanoparticle assemblies.
  • To explore their potential for emulating neuronal networks.

Main Methods:

  • Molecular dynamics (MD) simulations were employed.
  • Citrate-capped gold nanoparticles (cit-AuNPs) were linked by poly(allylamine hydrochloride) (PAH) chains of varying lengths.
  • Dimer, trimer, and tetramer structures were simulated.

Main Results:

  • Stable dimer, trimer, and tetramer structures were successfully built.
  • The tetramer structure demonstrated up to 11 distinct states with specific PAH linkers.
  • AuNP-AuNP distances were reduced, maintaining local stability over 10 ns MD simulations.
  • Global potential energy minimum observed at short distances due to electrostatic attraction.

Conclusions:

  • Polymer-networked gold nanoparticle assemblies exhibit structural stability.
  • These structures show potential for emulating neuronal networks and advancing computing.
  • Further improvements in stability and applications can be achieved with alternative materials.