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Conduction System of the Heart

Conduction System of the Heart

Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...

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Related Experiment Video

Updated: Oct 15, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

[New developments in leadless pacing systems].

Florian Doldi¹, Benedikt Biller², Florian Reinke²

¹Klinik für Kardiologie II - Rhythmologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1 Gebäude A1, 48149, Münster, Deutschland. Florian.Doldi@ukmuenster.de.

|October 23, 2021

Summary

This summary is machine-generated.

Leadless pacing systems offer a safe and effective alternative to traditional methods, especially for patients with difficult venous access. Future applications in cardiac resynchronization therapy show promise for reducing complications.

Keywords:

Arrhythmias, cardiac Bradycardia Defibrillator, subcutaneous Heart failure Resynchronization

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Last Updated: Oct 15, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Area of Science:

Cardiology
Medical Devices
Electrophysiology

Background:

Conventional transvenous pacing systems pose challenges, particularly in patients with difficult or impossible venous access.
Lead- and operation-associated complications are significant concerns with traditional pacing systems.

Purpose of the Study:

To evaluate the efficacy and safety of leadless pacing systems, specifically the Micra™ Transcatheter Pacing System (TPS).
To assess the compatibility of leadless pacemakers with other implantable electronic devices.
To explore the potential of leadless technology for cardiac resynchronization therapy.

Main Methods:

Review of clinical data on the Micra™ TPS system.
Assessment of device compatibility with subcutaneous implantable cardioverter-defibrillators (S-ICD) and deep brain stimulators.
Analysis of emerging data on leadless cardiac resynchronization therapy.

Main Results:

Leadless pacing systems, like Micra™ TPS, are effective and safe alternatives for patients with challenging venous access.
Compatibility with S-ICDs and deep brain stimulators is demonstrated without compromising efficacy or safety.
Leadless cardiac resynchronization therapy shows promising potential for preventing future complications.

Conclusions:

Leadless pacing represents a significant advancement, offering a viable solution for specific patient populations.
Device compatibility and the potential for leadless resynchronization therapy highlight the expanding role of this technology.
Current limitations in clinical adoption are primarily due to device availability and reimbursement issues, which are expected to improve with further data and increased implantation rates.