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Updated: Oct 15, 2025
11:01
Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography
Published on: January 18, 2020
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Bioinformatics in Immunoglobulin Glycosylation Analysis
Frédérique Lisacek1,2,3, Kathirvel Alagesan4, Catherine Hayes5,6
1Proteome Informatics Group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland. frederique.lisacek@sib.swiss.
Experientia Supplementum (2012)
|October 23, 2021
Summary
This chapter presents software and databases for analyzing immunoglobulin glycosylation, particularly for high-throughput IgG glycomic and glycoproteomic studies. Visualization tools help highlight glycan properties and differential expression.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Bioinformatics
Background:
- Immunoglobulin glycosylation analysis is crucial for understanding protein function.
- Specialized software is essential for processing complex glycomic and glycoproteomic data.
- High-throughput analysis of IgG glycosylation is increasingly important.
Purpose of the Study:
- To present a collection of analytical software and databases for immunoglobulin glycosylation.
- To detail specific applications in immunoglobulin glycomics and glycoproteomics workflows.
- To emphasize the utility of visualization tools for data interpretation.
Main Methods:
- Software compilation for immunoglobulin glycosylation analysis.
- Database curation for glycomic and glycoproteomic data.
- Development of data processing workflows for immunoglobulin glycomics.
- Application of visualization tools for glycoproteomics data analysis.
Main Results:
- A comprehensive collection of tools and databases for immunoglobulin glycosylation is provided.
- Workflows for glycomics and glycoproteomics data processing are detailed.
- Visualization tools effectively highlight glycan properties and differential expression.
Conclusions:
- The presented software and databases facilitate high-throughput immunoglobulin glycosylation analysis.
- Dedicated visualization tools enhance the interpretation of glycoproteomics data.
- This resource supports advanced glycomic and glycoproteomic characterization of immunoglobulins.
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