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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Perfusion MRI using endogenous deoxyhemoglobin as a contrast agent: Preliminary data.

Julien Poublanc1, Olivia Sobczyk1,2, Reema Shafi1

  • 1Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, Ontario, Canada.

Magnetic Resonance in Medicine
|October 23, 2021
PubMed
Summary
This summary is machine-generated.

Induced changes in blood oxygen levels can be mapped using BOLD MRI, demonstrating feasibility for cerebral perfusion imaging. This noninvasive method uses deoxyhemoglobin changes as a vascular contrast agent.

Keywords:
MRI contrastcerebral perfusiondeoxyhemoglobinendogenous contrasthypoxia

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Area of Science:

  • Neuroimaging
  • Cardiovascular Physiology
  • Medical Imaging

Background:

  • Cerebral perfusion imaging is crucial for diagnosing neurological disorders.
  • BOLD MRI is sensitive to changes in deoxyhemoglobin concentration.

Purpose of the Study:

  • To assess the feasibility of mapping cerebral perfusion metrics using BOLD MRI.
  • To investigate BOLD MRI's response to modulated pulmonary venous oxygen saturation.

Main Methods:

  • Rapid, isocapnic changes in arterial oxygen partial pressure were induced.
  • BOLD MRI tracked cerebral deoxyhemoglobin concentration changes in 6 healthy subjects and 1 patient.
  • Perfusion metrics (MTT, rCBV, rCBF) were calculated using a parametrized method with an arterial input function.

Main Results:

  • BOLD signal changes, CNR, and time delays were quantified in gray and white matter.
  • Significant differences in perfusion metrics were observed between gray and white matter.
  • Absolute cerebral blood flow and volume were calculated.

Conclusions:

  • Induced abrupt changes in deoxyhemoglobin serve as a noninvasive vascular contrast agent.
  • This method shows promise for advanced cerebral perfusion imaging.
  • Feasibility of mapping cerebral perfusion metrics with BOLD MRI is demonstrated.