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Structural valve deterioration of the Labcor Dokimos aortic prosthesis: a single-centre experience

Dounia Iskandarani1, Omar Chaabo1, Walid Gharzeddine1

  • 1Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon.

Interactive Cardiovascular and Thoracic Surgery
|October 23, 2021
PubMed

Insights

The Labcor Dokimos bioprosthetic aortic valve shows a high incidence of structural valve deterioration (SVD), primarily due to aortic regurgitation. This early deterioration necessitates further investigation in larger patient cohorts.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Medical Device Performance

Background:

  • Bioprosthetic aortic valves are crucial for treating aortic valve disease.
  • Assessing the long-term performance and durability of specific bioprosthetic valves is essential for clinical decision-making.

Purpose of the Study:

  • To evaluate the performance and incidence of structural valve deterioration (SVD) in the Labcor Dokimos bioprosthetic aortic valve.
  • To identify the primary causes and timing of SVD in this specific valve model.

Main Methods:

  • Retrospective review of 116 patients undergoing surgical aortic valve replacement with the Labcor Dokimos valve (2010-2018).
  • Analysis of patient demographics and echocardiographic data, categorizing patients into SVD and non-SVD groups.
  • Final analysis included 85 patients with complete follow-up data.

Main Results:

  • 38% (32/85) of patients developed SVD, with 26% (22/85) experiencing severe SVD.
  • Severe central aortic regurgitation was the most common cause of SVD (91% of severe cases).
  • The average time to severe SVD was 4.7 years.

Conclusions:

  • The Labcor Dokimos bioprosthetic aortic valve demonstrates a high and early incidence of deterioration, predominantly linked to severe aortic regurgitation.
  • These findings highlight the need for further investigation in larger registries to understand the long-term behavior of this valve.
  • Early SVD impacts patient outcomes and may require timely reintervention.
Abstract

Keywords:
Education cardiacTranscatheter valve therapyValve disease

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