Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

61.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
61.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D pathology-guided microdissection.

Nature methods·2026
Same author

Diagnostic techniques and detailed assessment of fetal intraspinal lipoma: a prospective study.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same author

Protective effects of beta-blockers against anthracycline- and trastuzumab-related cardiotoxicity: a systematic review based on conventional and Bayesian network meta-analysis.

Frontiers in cardiovascular medicine·2026
Same author

Piezoelectric Materials in Bone Organoids.

Advanced healthcare materials·2026
Same author

3D pathology-guided microdissection.

bioRxiv : the preprint server for biology·2025
Same author

Predictors of Postoperative Incisional Cerebrospinal Fluid Leak of Closed Spinal Dysraphism in Different Age Groups.

World neurosurgery·2025

Related Experiment Video

Updated: Oct 15, 2025

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors
08:26

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

9.4K

Conus medullaris migration during the third trimester: A retrospective study.

Mengchun Sun1,2, Benzhang Tao1, Gan Gao1

  • 1Department of Neurosurgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Prenatal Diagnosis
|October 23, 2021
PubMed
Summary

The conus medullaris (CM) migrates from L2 to L1/2 during the third trimester. This study establishes normal CM levels, aiding in the detection of fetal anomalies like tethered cord syndrome.

More Related Videos

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

15.1K
Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation
13:33

Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation

Published on: July 25, 2017

11.3K

Related Experiment Videos

Last Updated: Oct 15, 2025

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors
08:26

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

9.4K
Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

15.1K
Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation
13:33

Time-lapse Confocal Imaging of Migrating Neurons in Organotypic Slice Culture of Embryonic Mouse Brain Using In Utero Electroporation

Published on: July 25, 2017

11.3K

Area of Science:

  • Fetal Medicine
  • Neurology
  • Radiology

Background:

  • The precise location of the conus medullaris (CM) is crucial for diagnosing spinal abnormalities.
  • Understanding CM migration patterns in the third trimester is essential for accurate prenatal assessment.

Purpose of the Study:

  • To investigate the migration trajectory of the conus medullaris (CM) during the third trimester of pregnancy.
  • To establish normative ranges for CM levels in fetuses during this developmental period.

Main Methods:

  • Retrospective analysis of ultrasonographic and clinical data from 588 fetuses in the third trimester.
  • Statistical analysis using one-way ANOVA and linear regression to assess CM migration patterns.
  • CM levels were identified and scored, with significance set at p < 0.05.

Main Results:

  • Significant differences in CM levels were observed across different gestational weeks in the third trimester.
  • A linear regression correlation was identified between CM level and gestational age.
  • On average, the CM migrated from the upper third of the L2 vertebra to the L1/2 intervertebral disc level.

Conclusions:

  • The conus medullaris (CM) demonstrates continuous caudal migration throughout the third trimester, typically reaching the L1/2 intervertebral disc level by term.
  • Establishing normal CM ranges aids in identifying potential fetal spinal abnormalities, including tethered cord syndrome and caudal regression syndrome.
  • Specific CM locations at the beginning of the third trimester (above L2/3, at L3, or below L3) have distinct implications for fetal well-being and require appropriate follow-up.