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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Rejuvenating earlobe esthetics with dermal fillers.

Gulhima Arora1, Sandeep Arora2

  • 1Department of Dermatology, Mehektagul Dermaclinic, New Delhi, India.

Journal of Cosmetic Dermatology
|October 23, 2021
PubMed
Summary

Dermal fillers, particularly hyaluronic acid, offer a minimally invasive solution for ear lobe rejuvenation. This method effectively addresses aging signs and volume loss, restoring youthful aesthetics with lasting results and minimal downtime.

Keywords:
aestheticdermal fillersemi-permanent fillers

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Area of Science:

  • Aesthetic Medicine
  • Dermatology
  • Cosmetic Surgery

Background:

  • The ear lobe significantly impacts facial aesthetics, with aging and external factors like piercings causing sagging and volume loss.
  • Standard facial aesthetic procedures often overlook ear lobe aging.
  • Dermal fillers present a minimally invasive option for ear lobe rejuvenation, offering volume restoration and addressing morphological changes with limited side effects.

Purpose of the Study:

  • To review the selection of dermal fillers for ear lobule correction.
  • To elaborate on ear lobe anatomy and its influence on rejuvenation techniques, based on clinical experience and literature.

Main Methods:

  • Evaluation, treatment, and follow-up of patients receiving ear lobe fillers.
  • Comprehensive literature review on the use of hyaluronic acid fillers for ear lobule correction and rejuvenation.

Main Results:

  • Hyaluronic acid fillers provide a rapid and effective method for restoring ear lobe youthfulness and aesthetic appearance.
  • Fillers address aging indicators such as volume deficit, creases, and wrinkles, which may not be corrected by surgical methods.
  • The treatment is suitable for 'prejuvenation' in younger individuals anticipating heavy ear jewelry use, offering immediate, long-lasting results with minimal side effects and downtime.

Conclusions:

  • Hyaluronic acid fillers are a safe and effective tool for ear lobe rejuvenation.
  • This minimally invasive approach successfully restores volume, improves texture, and enhances the overall aesthetic of the ear lobe.
  • Dermal fillers offer a valuable alternative to surgery for addressing age-related changes and aesthetic concerns of the ear lobe.