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Updated: Oct 15, 2025
Assessment of Sexual Behavior of Male Mice
Published on: March 5, 2020
Hypothalamic cellular and molecular plasticity linked to sexual experience in male rats and mice
Arnaud Jean1, Sakina Mhaouty-Kodja1, Hélène Hardin-Pouzet1
1Sorbonne Université - Faculté de Sciences et Ingénierie, Neuroplasticité des Comportements de la Reproduction, Neurosciences Paris Seine, UM119 - CNRS UMR 8246 - INSERM UMRS 1130, 7 quai Saint Bernard, 75 005 Paris, France.
Abstract:
Male sexual behavior is subject to learning, resulting in increased efficiency of experienced males compared to naive ones. The improvement in behavioral parameters is underpinned by cellular and molecular changes in the neural circuit controlling sexual behavior, particularly in the hypothalamic medial preoptic area. This review provides an update on the mechanisms related to the sexual experience in male rodents, emphasizing the differences between rats and mice.
