Related Experiment Video

Updated: Oct 15, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.4K

The role of Siah2 in tumorigenesis and cancer therapy

Kailang Li1, Jinyun Li1, Meng Ye1

  • 1The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathphysiology, Medical School of Ningbo University, Ningbo 315211, China.

Gene
|October 23, 2021
PubMed

Insights

Seven in absentia homolog 2 (Siah2) plays a dual role in cancer, acting as both an oncogene and tumor suppressor. Understanding Siah2 regulation is key for developing targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Seven in absentia homolog 2 (Siah2) is an E3 ubiquitin ligase implicated in tumorigenesis and cancer progression.
  • Siah2's role is complex, promoting cancer in some malignancies while acting as a tumor suppressor in others.
  • Siah2 activity is tightly regulated, notably through phosphorylation by various protein kinases.

Purpose of the Study:

  • To review the structure and regulation of Siah2 in human cancer.
  • To highlight the critical role of Siah2 in tumorigenesis.
  • To discuss the potential clinical applications of targeting Siah2 in cancer therapy.

Main Methods:

  • Literature review of studies on Siah2 structure, regulation, and function in cancer.
  • Analysis of research on Siah2's involvement in various human malignancies.
  • Examination of studies investigating Siah2 phosphorylation and its impact on stability and activity.

Main Results:

  • Siah2 promotes tumorigenesis in prostate, lung, gastric, and liver cancers.
  • Siah2 can also function as a tumor suppressor by degrading oncoproteins.
  • Phosphorylation significantly impacts Siah2 stability and activity, influencing its biological functions.

Conclusions:

  • Siah2 exhibits context-dependent roles in cancer, acting as an oncoprotein or tumor suppressor.
  • Complex regulation, particularly phosphorylation, dictates Siah2's function.
  • Targeting Siah2 presents potential therapeutic strategies for cancer treatment.
Keywords:
Cancer therapyE3 ligasesOncoproteinSiah2Tumor suppressorTumorigenesis

More Related Videos

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.7K
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.6K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.4K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.2K