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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Decision Making in Subclinical Thyroid Disease.

Josh M Evron1, Maria Papaleontiou2

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, University of North Carolina, Burnett-Womack, CB 7172, Chapel Hill, NC 27599, USA.

The Medical Clinics of North America
|October 24, 2021
PubMed
Summary
This summary is machine-generated.

Subclinical thyroid disease, often found in clinics, may pose health risks. While subclinical hypothyroidism is linked to cardiovascular issues, treatment benefits remain unclear, and subclinical hyperthyroidism risks atrial fibrillation.

Keywords:
Decision makingSubclinical hyperthyroidismSubclinical hypothyroidism

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Area of Science:

  • Endocrinology
  • Internal Medicine
  • Clinical Practice

Background:

  • Subclinical thyroid disease is common.
  • Overt thyroid dysfunction has known adverse outcomes.
  • Implications of subclinical thyroid disease require further clarification.

Purpose of the Study:

  • To review the clinical implications of subclinical thyroid disease.
  • To assess the association between subclinical thyroid disease and adverse clinical outcomes.
  • To evaluate the evidence for thyroid hormone treatment in subclinical thyroid disease.

Main Methods:

  • Literature review of available data.
  • Analysis of associations between subclinical thyroid states and health risks.
  • Evaluation of treatment efficacy for cardiovascular risk reduction.

Main Results:

  • Subclinical hypothyroidism may increase cardiovascular disease and mortality risk.
  • Thyroid hormone treatment has not consistently shown cardiovascular risk reduction.
  • Subclinical hyperthyroidism is linked to atrial fibrillation and osteoporosis.
  • Association of subclinical hyperthyroidism with cardiovascular disease and death is uncertain.

Conclusions:

  • Subclinical thyroid disease carries potential risks, including cardiovascular disease and atrial fibrillation.
  • Treatment decisions for subclinical thyroid disease should consider TSH levels and comorbidities.
  • Further research is needed to clarify the long-term impact and optimal management of subclinical thyroid disease.