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Micro- and nanoformulations of paclitaxel based on micelles, liposomes, cubosomes, and lipid nanoparticles: Recent

Mehran Alavi1, Ali Nokhodchi2

  • 1Department of Nanobiotechnology, Faculty of Science, Razi University, Iran.

Drug Discovery Today
|October 24, 2021
PubMed

Insights

Paclitaxel (PTX) anticancer drug efficacy is limited by side effects and resistance. Micro- and nanoformulations like micelles, liposomes, cubosomes, and lipid nanoparticles (LNPs) show potential to improve PTX

Area of Science:

  • Pharmacology and Drug Delivery
  • Nanotechnology in Medicine
  • Cancer Therapeutics

Background:

  • Paclitaxel (PTX), a diterpenoid from Taxus brevifolia, is a key anticancer drug for ovarian and breast cancers.
  • Widespread clinical application of PTX is constrained by dose-limiting toxicities and acquired chemoresistance.
  • Novel drug delivery systems are crucial for enhancing PTX therapeutic index.

Purpose of the Study:

  • To review micro- and nanoformulations of paclitaxel (PTX).
  • To explore the potential of micelles, liposomes, cubosomes, and lipid nanoparticles (LNPs) in overcoming PTX limitations.
  • To summarize advancements in PTX nanoformulations for improved anticancer efficacy.

Main Methods:

  • Literature review of micro- and nanoformulations of paclitaxel.
  • Analysis of studies utilizing micelles, liposomes, cubosomes, and LNPs for PTX delivery.
  • Evaluation of in vitro and in vivo data on the therapeutic effects of PTX nanoformulations.

Main Results:

  • Various nanoformulations (micelles, liposomes, cubosomes, LNPs) demonstrate potential to mitigate PTX adverse effects.
  • These systems can enhance drug solubility and stability, improving bioavailability.
  • Evidence suggests improved efficacy and reduced resistance in preclinical models using PTX nanoformulations.

Conclusions:

  • Micro- and nanoformulations offer a promising strategy to enhance paclitaxel's therapeutic utility.
  • Lipid-based nanoparticles, including liposomes and LNPs, are particularly effective for PTX delivery.
  • Further research into these advanced delivery systems can optimize cancer treatment outcomes.
Keywords:
CubosomesLipid nanoparticlesLiposomesMicellesNanoformulationsPaclitaxel

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