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Comprehending fibroblast growth factor receptor like 1: Oncogene or tumor suppressor?

Aprajita1, Rinu Sharma1

  • 1University School of Biotechnology, Guru Gobind Singh Indraprastha University, Dwarka, New Delhi, India.

Cancer Treatment and Research Communications
|October 24, 2021
PubMed

Insights

Fibroblast Growth Factor Receptor Like 1 (FGFRL1) impacts cell processes and cancer. Inhibiting FGFRL1 may offer therapeutic benefits for human cancer prognosis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Fibroblast Growth Factor Receptor Like 1 (FGFRL1) signaling is vital in genetic diseases, development, and cancer.
  • Initially considered a decoy receptor due to lacking a tyrosine kinase domain, FGFRL1's role has expanded.

Purpose of the Study:

  • To review the current understanding of FGFRL1.
  • To explore FGFRL1's involvement in cell differentiation, adhesion, and proliferation pathways.
  • To assess the potential of FGFRL1 as a therapeutic target in cancer.

Main Methods:

  • Literature review of existing studies on FGFRL1.
  • Analysis of FGFRL1's impact on key signaling pathways (e.g., ERK1/2, Akt).
  • Examination of FGFRL1 expression in relation to tumor progression and invasion.

Main Results:

  • FGFRL1 influences critical cellular pathways like ERK1/2 and Akt, often dysfunctional in cancers.
  • Overexpression of FGFRL1 correlates with increased tumor progression and invasion.
  • Evidence suggests FGFRL1's involvement in cell differentiation, adhesion, and proliferation.

Conclusions:

  • FGFRL1 plays a significant role in cellular processes relevant to cancer.
  • Targeting FGFRL1 with inhibitors could present a novel therapeutic strategy for improving cancer prognosis.
Keywords:
CancerFibroblast growth factor receptorInhibitorsOncogenePhylogenetic analysisSignaling pathways

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