Related Experiment Video

Updated: Oct 15, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Predicting Stroke Complications in Hospital and Functional Status at Discharge by Clustering of Cardiovascular

Thang S Han1, Christopher H Fry2, David Fluck3

  • 1Institute of Cardiovascular Research, Royal Holloway University of London, Egham, TW20 0EX, UK.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 24, 2021
PubMed

Insights

A new tool using cardiovascular disease (CVD) clusters, called CASH, helps predict acute stroke outcomes. Higher CASH scores indicate increased risks for mortality, disability, and infections after stroke.

Area of Science:

  • Neurology
  • Cardiology
  • Public Health

Background:

  • Predicting outcomes after acute stroke remains challenging.
  • Existing indicators for acute stroke outcomes are limited.
  • Coexisting cardiovascular disease (CVD) may influence stroke outcomes.

Purpose of the Study:

  • To develop and validate evidence-based criteria for identifying acute stroke outcomes.
  • To assess the association between clusters of coexisting cardiovascular disease (CVD) and adverse stroke outcomes.

Main Methods:

  • Analysis of prospectively collected data from the Sentinel Stroke National Audit Programme (SSNAP) between 2014 and 2016.
  • Inclusion of 3309 patients admitted with acute stroke to UK hyperacute stroke units.
  • Development of the Cardiovascular disease, Atrial fibrillation, pre-existing Stroke and Hypertension (CASH) score, categorizing patients into CASH-0 to CASH-3 based on the number of coexisting CVDs.

Main Results:

  • Patients with CASH-3 (three or four coexisting CVDs) exhibited significantly higher risks of in-hospital mortality (OR=1.8) and disability at discharge (OR=1.9) compared to CASH-0.
  • Increased risks of urinary tract infection (OR=3.3), pneumonia (OR=2.6), and prolonged length of stay (>14 days) (OR=1.8) were observed in the CASH-3 group.
  • A higher likelihood of joint care planning (OR=1.4) was also associated with the CASH-3 category.

Conclusions:

  • The CASH score serves as a simple, evidence-based tool for estimating the risk of adverse outcomes following acute stroke.
  • CASH-0 signifies a low risk, while CASH-3 indicates a high risk for complications such as mortality, disability, infections, and prolonged hospital stay.
  • This tool can aid clinicians in risk stratification and management planning for acute stroke patients.
Abstract

Keywords:
Healthcare economicsLength of stayMorbidityMortalityMultimorbidityNosocomial infections

More Related Videos

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.2K
Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

8.8K

Related Concept Videos

Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
98
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
44