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Emerging roles for IL-11 in inflammatory diseases
Ka Yee Fung1, Cynthia Louis2, Riley D Metcalfe3
1Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Victoria 3053, Australia.
Cytokine
|October 24, 2021
Summary
Interleukin-11 (IL-11) is a cytokine linked to fibrosis and cancer. This review explores IL-11
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Interleukin-11 (IL-11) is a cytokine implicated in fibrotic diseases and solid tumors.
- Its role in non-malignant inflammatory diseases is less understood.
- Elevated IL-11 expression is observed in various chronic inflammatory conditions.
Purpose of the Study:
- To summarize the current literature on IL-11's contribution to autoimmune and chronic inflammatory diseases.
- To elucidate the function of IL-11 in conditions beyond malignancy and fibrosis.
Main Methods:
- Literature review of studies investigating IL-11 in inflammatory diseases.
- Analysis of existing research on IL-11's pathogenic roles.
Main Results:
- IL-11 is involved in the pathogenesis of rheumatoid arthritis, multiple sclerosis, diabetes, and systemic sclerosis.
- IL-11 also contributes to periodontitis, asthma, COPD, psoriasis, and colitis.
- Evidence suggests IL-11 plays a significant role in diverse inflammatory conditions.
Conclusions:
- Interleukin-11 is a key cytokine in the pathogenesis of numerous autoimmune and chronic inflammatory diseases.
- Understanding IL-11's function is crucial for developing targeted therapies for these conditions.
- Further research is warranted to fully characterize IL-11's mechanisms in non-malignant inflammation.
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