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Updated: Oct 15, 2025
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Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
Published on: March 5, 2019
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Innate immunity and clinical hypertension
Justin P Van Beusecum1,2,3, Hietor Moreno4, David G Harrison5,6
1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Journal of Human Hypertension
|October 24, 2021
Summary
Inflammation and immunity play key roles in hypertension development. Targeting immune mediators like cytokines can reduce high blood pressure and organ damage.
Area of Science:
- Immunology
- Cardiovascular Research
- Nephrology
Background:
- Emerging evidence implicates inflammation and immunity in hypertension pathogenesis.
- Immune cells infiltrate cardiovascular and renal tissues, releasing mediators that cause damage and elevate blood pressure.
- Hypertension-associated factors like sympathetic outflow and sodium activate immune cells.
Purpose of the Study:
- To review the mechanisms linking inflammation and immunity to hypertension.
- To explore how immune cell activation and mediator release contribute to hypertensive end-organ damage.
- To discuss novel therapeutic strategies targeting inflammation in hypertension.
Main Methods:
- Review of existing literature on inflammation, immunity, and hypertension.
- Analysis of immune cell involvement in hypertensive models and human studies.
- Examination of specific inflammatory mediators (cytokines, ROS) and their roles.
Main Results:
- Immune cells, including monocytes and T cells, are activated in hypertension.
- Mediators like IL-6, IL-1β, IL-23, and IL-17A are crucial in promoting hypertension and end-organ damage.
- Genetic deletion or neutralization of these cytokines alleviates hypertension and associated damage.
Conclusions:
- Inflammation and immune responses are integral to hypertension and its complications.
- Targeting specific inflammatory pathways, particularly cytokines, offers promising therapeutic avenues.
- Further research into the hypertensive milieu's impact on immune cells is warranted for developing effective treatments.
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