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Carica papaya mouthrinse as an inhibitor of Streptococcus mutans: Randomized controlled clinical trial
Diego Cespedes1, Julieta Mendez2, Ulises Villasanti1
1Faculty of Dentistry, National University of Caaguazú, Coronel Oviedo, Paraguay.
Purpose:
To evaluate the effect of Carica papaya mouthrinse as an inhibitor of Streptococcus mutans.
Methods:
This was a double blind (subject and evaluator) randomized controlled trial in 40 subjects distributed in two groups: Carica papaya mouthrinse intervention (n= 20) or chlorhexidine (n= 20). The antibacterial effect was determined by counting colony-forming units per milliliter (CFU/ml) of S. mutans in saliva sample cultures; taken both before mouthrinse, immediately after 10 minutes mouthrinsing, and 8 days after mouthrinsing. The data was statistically analyzed with Student's t-test (P ≤ 0.05).
Results:
The difference before and immediately after (10 minutes) use of Carica papaya mouthrinse was of 764 CFUs. After 8 days use the difference was 212 CFUs. For the control group (0.12% chlorhexidine) the difference before and immediately after use (10 minutes) was 683 CFUs. After 8 days use the difference was 455 CFU. When comparing between groups applying t-test, no statistical differences were found in the (CFU/ml) of S. mutans before and after 10 minutes mouthrinse (P= 0.8060), 10 minutes and 8 days after mouthrinsing (P= 0.7104) before and 8 days after mouthrinsing (P= 0.4419).
Clinical Significance:
Carica papaya could be an alternative mouthrinse for the inhibition of Streptococcus mutans.
