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Long non-coding RNA HEIH: a novel tumor activator in multiple cancers
1Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.
Cancer Cell International
|October 25, 2021
Summary
Long non-coding RNA HEIH is frequently upregulated in cancers, promoting tumor growth and resistance. Its elevated expression correlates with poor survival, indicating HEIH is a potential cancer biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA HEIH (highly expressed in cancer) shows altered expression in various cancers.
- Recent research highlights HEIH's significant role in carcinogenesis, with most studies published in the last two years.
Purpose of the Study:
- To review recent developments and insights into the role of HEIH in cancer.
- To detail the functional role, molecular mechanisms, and clinical significance of HEIH in human cancers.
Main Methods:
- Literature review of recent studies on HEIH in cancer.
- Analysis of HEIH expression levels, functional roles, and clinical associations.
Main Results:
- HEIH expression is elevated across a wide range of cancers.
- Upregulated HEIH promotes cancer cell proliferation, migration, invasion, and drug resistance via diverse mechanisms.
- High HEIH expression is linked to advanced tumor stage, larger tumor size, and reduced overall survival.
Conclusions:
- HEIH plays a critical role in cancer development and progression.
- HEIH serves as a potential prognostic biomarker for human cancers.
- HEIH represents a promising therapeutic target for cancer treatment.
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