Related Experiment Video

Updated: Oct 15, 2025

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.2K

Morphological and functional cardiac consequences of rapid hypertension treatment: a cohort study

Andrew N Jordan1,2,3, Jon Fulford4,5, Kim Gooding4,5

  • 1Vascular Medicine, NIHR Exeter Clinical Research Facility, Exeter, UK. andrewjordan@doctors.org.uk.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|October 25, 2021
PubMed

Insights

Intensive treatment of grade II/III hypertension within 18 weeks significantly reduced left ventricular hypertrophy (LVH) and improved cardiac function. This rapid approach supports the hypothesis that early hypertension control enhances clinical outcomes.

Area of Science:

  • Cardiology
  • Hypertension Management
  • Cardiac Imaging

Background:

  • Left ventricular hypertrophy (LVH) in uncontrolled hypertension independently predicts mortality.
  • Regression of LVH with treatment improves patient outcomes.
  • Current guidelines recommend treating severe hypertension within 3 months, but the impact of very early LVH regression (18 weeks) remains under investigation.

Purpose of the Study:

  • To investigate the effects of a rapid, guideline-based hypertension treatment protocol on left ventricular (LV) remodeling.
  • To determine if achieving blood pressure (BP) control within 18 weeks is associated with improvements in LV structure and function.
  • To utilize cardiovascular magnetic resonance (CMR) for precise assessment of LV mass and feature tracking.

Main Methods:

  • Recruited participants with never-treated grade II/III hypertension.
  • Initiated a guideline-based treatment protocol aiming for BP control within 18 weeks.
  • Performed paired CMR scans at baseline and 18 weeks, employing feature tracking analysis for myocardial morphology and function.

Main Results:

  • Significant reduction in LV mass index (p < 0.001) after 18 weeks of treatment.
  • Accompanied by significant reductions in LV ejection fraction (p = 0.03) and global radial strain (p < 0.001).
  • Demonstrated significant decreases in mid-circumferential strain (p = 0.02), apical circumferential strain (p = 0.003), and apical rotation (p = 0.003).

Conclusions:

  • LVH regresses within 18 weeks of intensive antihypertensive treatment in newly diagnosed severe hypertension.
  • This regression is associated with potentially beneficial functional changes in the myocardium.
  • Supports the hypothesis that rapid hypertension treatment can lead to improved clinical outcomes.
Abstract

Keywords:
Feature trackingHypertensionLeft ventricular hypertrophyRapid treatmentStrainTorsion

More Related Videos

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.6K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

4.0K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
101
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
103
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
172
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
94
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.3K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K