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Osmotic-controlled release oral tablets: technology and functional insights.
Kenneth S Ogueri1, Sheri L Shamblin1
1Pfizer Inc., Groton, CT 06340, USA.
Trends in Biotechnology
|October 25, 2021
Summary
Oral osmotic tablets offer controlled drug release, unaffected by body conditions. This review explores swellable core technology for optimal zero-order release, addressing design challenges and future opportunities in osmotic drug delivery systems.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Controlled Release Formulations
Background:
- Oral osmotic tablets represent a significant advancement in controlled-release drug delivery.
- Their key advantage is inherent stability against physiological and physicochemical variations.
- However, challenges in design and optimization hinder their full potential.
Purpose of the Study:
- To systematically review the development of osmotic-driven drug delivery systems.
- To explore strategies for achieving zero-order drug release profiles.
- To emphasize the role of swellable core technology in osmotic tablet design.
Main Methods:
- Literature review of osmotic tablet development and technologies.
- Analysis of factors influencing osmotic tablet design and selection.
- Discussion of swellable core technology for controlled release.
Main Results:
- Osmotic tablets offer predictable drug release, independent of biological variability.
- Swellable core technology is a key strategy for achieving zero-order release kinetics.
- Various osmotic tablet types exist, each suited for specific therapeutic needs.
Conclusions:
- Despite manufacturing and optimization challenges, osmotic tablets hold significant therapeutic promise.
- Further research into functional mechanics and bio-performance optimization is needed.
- Future perspectives include overcoming current limitations and expanding applications of osmotic drug delivery.
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