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Published on: April 18, 2019
Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus
Vigyasa Singh1,2, Anirban Pal1, Mahendra P Darokar1
1Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants.
Abstract:
Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, affected macromolecules' (DNA, lipid, protein) integrity and distorted cell morphology. We found correlation between drug-effects and up-/down-regulation of oxidative stress-related as well as MDR genes. These findings could considerably potentiate the dosing routine of Nor in combination with Glb, which holds a promising prospective as a antibacterial agent against S. aureus.
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