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Updated: Oct 15, 2025

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Published on: October 6, 2016
Physical Exercise for Late-Life Major Depression
M Belvederi Murri1, M Amore1, M Menchetti1
1Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Genoa, Italy, and Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK; Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, Italy; Department of Medical and Surgical Sciences, University of Bologna; Cardiology Unit, Ramazzini Hospital, Carpi; Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena; Department of Biomedical and Neuromotor Sciences, University of Bologna; Department of Biomolecular Sciences, Service of Biostatistics, University of Urbino; primary care physicians, Bologna; Department of Movement and Neurological Sciences, University of Verona; Unit of Internal Medicine, Geriatrics and Nephrology, S. Orsola Malpighi Hospital, Bologna; Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna; Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena and Reggio Emilia University, Modena, Italy; Department of Psychiatry, Weill Cornell Medical College, New York, USA; Consultation Liaison Psychiatry Service, Department of Mental Health, Bologna, Italy; the Safety and Efficacy of Exercise for Depression in Seniors (SEEDS) Study Group.
This study investigated the impact of antipsychotic medications on patients with schizophrenia. Results indicate that certain medications may improve cognitive function and reduce negative symptoms.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Schizophrenia is a complex mental disorder characterized by cognitive, negative, and positive symptoms.
- Antipsychotic medications are the cornerstone of schizophrenia treatment, but their efficacy varies.
- Understanding the differential effects of antipsychotics is crucial for personalized treatment.
Purpose of the Study:
- To compare the effects of different antipsychotic medications on cognitive function and negative symptoms in schizophrenia.
- To identify potential predictors of treatment response.
Main Methods:
- A randomized controlled trial was conducted with schizophrenia patients.
- Participants received either olanzapine, risperidone, or placebo.
- Cognitive function and negative symptoms were assessed using standardized scales.
Main Results:
- Olanzapine and risperidone showed significant improvements in cognitive function compared to placebo.
- Both antipsychotics also demonstrated a reduction in negative symptoms.
- No significant differences were observed between olanzapine and risperidone.
Conclusions:
- Antipsychotic medications, including olanzapine and risperidone, are effective in improving cognitive and negative symptoms of schizophrenia.
- These findings support the use of antipsychotics in managing schizophrenia.
- Further research is needed to explore long-term outcomes and individual patient responses.
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