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In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

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Monitoring Visual Cortical Activities During Progressive Retinal Degeneration Using Functional Bioluminescence

Darryl Narcisse¹, Sourajit M Mustafi¹, Michael Carlson¹

¹Nanoscope Technologies LLC, Bedford, TX, United States.

Frontiers in Neuroscience

|October 25, 2021

Summary

This summary is machine-generated.

Researchers monitored brain activity in mouse models of retinitis pigmentosa. Calcium-bioluminescence imaging revealed declining visual cortex function correlating with retinal degeneration and vision loss.

Keywords:

bioluminescence functional imaging multi-characteristic opsin retinal degeneration visually-evoked activity

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Area of Science:

Neuroscience
Ophthalmology
Biomedical Imaging

Background:

Inherited retinal degenerative diseases cause photoreceptor loss, impacting visual signal transmission to the brain.
Mouse models like RD10 mice exhibit progressive retinal degeneration, mimicking human conditions such as retinitis pigmentosa.

Purpose of the Study:

To longitudinally monitor and quantify visual cortical activity changes in response to visual stimuli during the progression of retinal degeneration in RD10 mice.
To establish a Ca2+-bioluminescence monitoring method as a viable imaging modality for assessing visual cortex function in models of retinal disease.

Main Methods:

Utilized Ca2+-bioluminescence imaging to measure neural activity in the visual cortex of RD10 mice.
Correlated neural activity metrics with electroretinography (ERG) signals and retinal thinning measured by Optical Coherence Tomography (OCT).

Main Results:

Visual cortical activity, including the number of active neurons and response intensity, progressively deteriorated with age in RD10 mice.
Deterioration in visual cortex activity directly correlated with declining ERG signals and progressive retinal degeneration.
Retinal thinning, assessed via OCT, was found to correlate with decreased visual cortical activity.

Conclusions:

Ca2+-bioluminescence monitoring effectively characterizes longitudinal changes in visual cortex activity during retinal degeneration.
This imaging approach provides a valuable tool for studying disease progression and evaluating therapeutic interventions in mouse models of inherited retinal diseases.