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Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging.

Stefano Ministrini1,2, Yustina M Puspitasari1, Georgia Beer1

  • 1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.

Frontiers in Physiology
|October 25, 2021
PubMed
Summary
This summary is machine-generated.

Sirtuin 1 (SIRT1) is an enzyme linked to aging and lifespan. Reduced SIRT1 function contributes to cellular senescence, endothelial dysfunction, and age-related cardiovascular diseases.

Keywords:
aging–old age–seniorsatherosclerosiscardiovascular diseaseeNOS (endothelial nitric oxide synthase)endothelial (dys)functioninflammagingsirtuin (SIRT1)

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Sirtuin 1 (SIRT1) is an NAD+-dependent enzyme with crucial metabolic roles.
  • SIRT1 is involved in regulating cell survival under various stimuli.
  • SIRT1 expression declines with aging, impacting healthspan.

Purpose of the Study:

  • To review evidence linking SIRT1 defects to aging and cardiovascular diseases.
  • To explore the role of SIRT1 in endothelial dysfunction.
  • To identify future research directions and translational perspectives.

Main Methods:

  • Literature review of existing studies on SIRT1, aging, and cardiovascular disease.
  • Analysis of functional and quantitative defects of SIRT1.
  • Synthesis of data on cellular senescence and endothelial function.

Main Results:

  • Functional and quantitative SIRT1 defects are associated with cellular senescence.
  • Reduced SIRT1 contributes to endothelial dysfunction.
  • SIRT1 deficiency is implicated in age-related cardiovascular pathologies.

Conclusions:

  • SIRT1 plays a critical role in mitigating aging-related cellular damage.
  • Therapeutic strategies targeting SIRT1 may offer potential for cardiovascular disease prevention.
  • Further research is needed to fully elucidate SIRT1's translational applications.