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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Oct 15, 2025

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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Low GNG12 Expression Predicts Adverse Outcomes: A Potential Therapeutic Target for Osteosarcoma.

Jinghong Yuan1, Zhao Yuan2, Aifang Ye3

  • 1Department of Orthopaedics, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Immunology
|October 25, 2021
PubMed
Summary

G protein subunit gamma 12 (GNG12) is decreased in osteosarcoma and acts as a prognostic biomarker. Lower GNG12 expression correlates with poorer survival and may indicate potential for immunotherapy in osteosarcoma.

Keywords:
GNG12biomarkerosteosarcomaprognosistherapeutic target

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • G protein subunit gamma 12 (GNG12) is implicated in various cancers, but its role in osteosarcoma remains unelucidated.
  • This study investigated GNG12 as a potential diagnostic biomarker and therapeutic target for osteosarcoma.

Purpose of the Study:

  • To determine the association between GNG12 expression and osteosarcoma.
  • To evaluate GNG12's potential as a prognostic biomarker and therapeutic target in osteosarcoma.

Main Methods:

  • Utilized Gene Expression Omnibus (GEO) and Therapeutically Applicable Research to Generate Effective Treatments (TARGET) databases for analysis.
  • Performed functional annotation, gene expression correlation, and competing endogenous RNA (ceRNA) network construction.
  • Assessed GNG12's prognostic value using Kaplan-Meier analysis and receiver operating characteristic (ROC) curves.

Main Results:

  • GNG12 expression was significantly decreased in osteosarcoma tissues compared to normal tissues.
  • GNG12 demonstrated high diagnostic accuracy (AUC=0.920) and predicted patient survival (overall and progression-free).
  • GNG12 may regulate osteosarcoma progression via endoplasmic reticulum pathways and suppress adaptive immunity by inhibiting macrophage infiltration.

Conclusions:

  • GNG12 serves as a promising prognostic biomarker for osteosarcoma.
  • GNG12 represents a potential therapeutic target, particularly for immunotherapy, in osteosarcoma treatment.