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Updated: Oct 15, 2025
Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Serum sTREM-1 and CXCL-16 Levels in Children with Mycoplasma pneumoniae Pneumonia and Their Diagnostic Value
Chengchao Fang1, Yueyan Mao1, Mingfen Jiang2
1Department of Pediatrics, The First People's Hospital of Yuhang, Yuhang District, Hangzhou, Zhejiang 311100, China.
Abstract:
Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory tract infection caused by Mycoplasma pneumoniae. It is characterized by severe symptoms, long course of disease, many intrapulmonary complications, and poor therapeutic effect. In recent years, the incidence of Mycoplasma infection have been gradually rising trend, and the children's own immune system development is not mature, cases differences, children with mild can only show the upper respiratory tract infection, and critically ill children can lead to lung infection and even lead to multiple organ dysfunction, affect life and health of children. Soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) is a subtype secreted by myeloid cell trigger receptor-1, which is released into blood in large amounts when the body is infected, and is a newly discovered inflammatory indicator in recent years. CXC chemokine 16 (CXCL-16) can recruit lymphocytes by chemotaxis through binding to its receptor CXCR6 to participate in the body's immune regulation. The purpose of this study was to investigate serum sTREM-1 and CXCL-16 levels in children with MPP and to analyze their correlation with the disease and diagnostic value. The results showed that the serum levels of sTREM-1 and CXCL-16 were increased in children with Mycoplasma. Serum levels of sTREM-1 and CXCL-16 were positively correlated with the severity of the disease. sTREM-1 combined with CXCL-16 has an important value in the diagnosis of children with MPP.
Insights
Serum levels of soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) and CXC chemokine 16 (CXCL-16) are elevated in children with Mycoplasma pneumoniae pneumonia (MPP). These biomarkers correlate with disease severity and aid in MPP diagnosis.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
- Biomarker Research
Background:
- Mycoplasma pneumoniae pneumonia (MPP) is a severe respiratory infection in children with increasing incidence.
- Pediatric immune systems are immature, leading to varied disease presentations and complications.
- Soluble triggering receptors expressed on myeloid cell-1 (sTREM-1) and CXC chemokine 16 (CXCL-16) are emerging inflammatory and immune regulatory markers.
Purpose of the Study:
- To investigate serum sTREM-1 and CXCL-16 levels in children diagnosed with MPP.
- To analyze the correlation between these biomarker levels and disease severity in pediatric MPP.
- To evaluate the diagnostic value of sTREM-1 and CXCL-16, individually and in combination, for pediatric MPP.
Main Methods:
- Serum samples were collected from children with MPP and control groups.
- Quantification of serum sTREM-1 and CXCL-16 levels using appropriate laboratory techniques.
- Statistical analysis to determine correlations between biomarker levels, disease severity, and diagnostic accuracy.
Main Results:
- Children with MPP exhibited significantly higher serum levels of sTREM-1 and CXCL-16 compared to controls.
- Elevated sTREM-1 and CXCL-16 levels were positively correlated with the clinical severity of MPP.
- The combined analysis of sTREM-1 and CXCL-16 demonstrated significant diagnostic value for pediatric MPP.
Conclusions:
- Serum sTREM-1 and CXCL-16 are elevated in pediatric MPP.
- These biomarkers serve as indicators of disease severity in children with MPP.
- Combined sTREM-1 and CXCL-16 levels offer valuable diagnostic potential for pediatric MPP.
