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Metastatic and locally aggressive BCC: Current treatment options
Máire-Caitlín Casey1, Roisín Pollock1, Rachel H Enright1
1Beaumont Head & Neck Department Beaumont Hospital Dublin Ireland.
Clinical Case Reports
|October 25, 2021
Summary
Advanced basal cell carcinoma (BCC) is challenging to treat. New options include hedgehog inhibitors (Vismodigib, Sonidigib) and Cemiplimab immunotherapy, improving treatment strategies.
Area of Science:
- Oncology
- Dermatology
Background:
- Locally advanced and metastatic basal cell carcinoma (BCC) pose significant clinical challenges.
- Traditional treatment modalities have limitations for advanced BCC cases.
Observation:
- Recent advancements have introduced novel therapeutic agents for BCC.
- Hedgehog pathway inhibitors and immune checkpoint inhibitors represent a paradigm shift.
Findings:
- Vismodigib and Sonidegib are hedgehog inhibitors demonstrating efficacy in BCC treatment.
- Cemiplimab, an immunotherapy agent, offers a new avenue for managing advanced BCC.
Implications:
- These new treatments expand therapeutic options for patients with advanced BCC.
- Further research is warranted to optimize the use of these agents in BCC management.
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