Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

20.8K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
20.8K
Nucleic acids02:43

Nucleic acids

178.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
178.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint Impact of Triglyceride-glucose Index and Free Fatty Acid Levels on Cardiovascular Outcomes in Overweight or Obese Patients with Coronary Artery Disease - A Large Multicenter Prospective Study.

Biomedical and environmental sciences : BES·2026
Same author

Unveiling clinical decision-making in pediatric surgery: how frontline staff perform and what shapes their skills.

BMC medical education·2026
Same author

Longitudinal Association Between Bullying Victimization and Pediatric Functional Gastrointestinal Disorders (FGIDs) in Chinese Adolescents: Trajectories and Bidirectional Associations.

Research on child and adolescent psychopathology·2026
Same author

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial.

Drug design, development and therapy·2026
Same author

Corrigendum to "GZR18, a novel long-acting GLP-1 analog, demonstrated positive in vitro and in vivo pharmacokinetic and pharmacodynamic characteristics in animal models" [Europ. J. Pharmacol. 928 (2022) 175107].

European journal of pharmacology·2026
Same author

Multiplex graph prompt learning and attentive fusion for event graph completion.

Neural networks : the official journal of the International Neural Network Society·2026

Related Experiment Video

Updated: Oct 15, 2025

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

24.0K

Lipid-oligonucleotide conjugates for bioapplications.

Xiaowei Li1, Kejun Feng1, Long Li1

  • 1Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.

National Science Review
|October 25, 2021
PubMed
Summary
This summary is machine-generated.

Lipid-oligonucleotide conjugates (LONs) are versatile materials for biosensing and biomedicine. This review highlights their synthesis, characterization, and applications in cellular force measurement, imaging, and targeted therapy.

Keywords:
DNA nanostructurebioanalysisbiomedicinebiosensorlipid–oligonucleotidenanoreactor

More Related Videos

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries
08:10

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Published on: August 23, 2024

4.8K
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.3K

Related Experiment Videos

Last Updated: Oct 15, 2025

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

24.0K
Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries
08:10

Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries

Published on: August 23, 2024

4.8K
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.3K

Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Lipid-oligonucleotide conjugates (LONs) possess unique amphiphilic structures facilitating self-assembly and information transfer.
  • Their applications span biosensors, biomedicine, intracellular imaging, and biomimetic engineering.

Purpose of the Study:

  • To review general synthesis strategies for LONs.
  • To highlight recent advances in bioanalytical and biomedical applications of LONs.
  • To discuss challenges and future directions for LON development.

Main Methods:

  • General synthesis strategies for LONs are summarized.
  • Characterization techniques for LONs are discussed.
  • Recent advancements in LON applications are emphasized.

Main Results:

  • LONs show potential in measuring cellular mechanical forces and monitoring cell behaviors.
  • LONs are effective for intracellular imaging and developing cell-surface nanostructures.
  • LONs can incorporate therapeutic agents for targeted therapy and mediate vesicle fusion for nanoreactors.

Conclusions:

  • LONs are powerful tools with diverse applications in bioanalysis and biomedicine.
  • Further research can enhance LON functionality for nanotechnology and materials science.
  • Continued development promises improved targeted therapies and advanced nanostructures.