Diffusion of oral ofloxacin (HOE 280) into human prostatic tissue: assessment by an improved high-performance liquid chromatographic method

11 patients with a prostatic adenoma received a single oral 200 mg dose of ofloxacin 2 h before transurethral resection of the prostate. During the operation, blood samples and prostatic tissue cuttings were collected simultaneously. Ofloxacin was assayed by an original HPLC method with UV detection. The mean concentration of the unchanged drug was 5.10 mg/kg wet tissue and 1.81 mg/l in prostatic tissue and plasma, respectively. The 3.17 prostate/plasma ratio reflected a good penetration of ofloxacin into the prostatic tissue.