Effect of cis-platinum on the protein binding and pharmacokinetics of 67Ga-citrate

Cis-platinum, a widely used chemotherapeutic drug, and K2PtCl4, a related complex, were found to inhibit the in vitro protein binding of 67Ga to human transferrin in isolated solution but not to whole serum. Cis-platinum treatment of rabbits resulted in enhanced protein binding and delayed blood clearance of subsequently injected 67Ga-citrate. These effects are related to the toxicity of the drug in vivo.