Genome editing in large animals: current status and future prospects.

Area of Science:

• Biotechnology
• Genetics
• Animal Science

Background:

• Large animals are crucial models in biomedical research and vital agricultural resources.
• Advancements in programmable DNA nucleases have transformed gene modification in these animals.

Purpose of the Study:

• To review recent progress in nuclease-mediated gene editing tools.
• To outline applications of these tools in human disease modeling, regenerative medicine, and agriculture.

Main Methods:

• Review of recent scientific literature on nuclease-mediated gene editing.
• Analysis of applications in various research and agricultural fields.

Main Results:

• Nuclease technologies have significantly advanced the generation of gene-modified large animals.
• These tools show broad applicability across biomedical and agricultural sectors.

Conclusions:

• Genome editing technologies offer significant potential for advancing biological research and agriculture.
• Challenges and future prospects of these technologies require further consideration.