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Related Experiment Video

Updated: Oct 15, 2025

Biofunctionalization of Magnetic Nanomaterials
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Cell membrane-covered nanoparticles as biomaterials.

Mingjun Xuan1, Jingxin Shao1, Junbai Li1

  • 1Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China.

National Science Review
|October 25, 2021
PubMed
Summary

Cell membrane cloaking shields synthetic nanocarriers from immune systems, enhancing drug delivery. This biomimetic approach improves therapeutic efficacy and reduces toxicity for advanced nanomedicine applications.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Immunology

Background:

  • Surface engineering of synthetic carriers is crucial for *in vivo* drug delivery.
  • Synthetic nanosystems often trigger immune clearance, leading to poor efficacy and toxicity.
  • Cell membrane cloaking offers a novel biological approach to improve nanocarrier performance.

Purpose of the Study:

  • To review cell membrane-covered nanosystems.
  • To highlight the novelty and biomedical applications of these biomimetic systems.
  • To describe future prospects for cell membrane-cloaked nanocarriers.

Main Methods:

  • Review of existing literature on cell membrane cloaking techniques.
  • Analysis of the immunological and physiochemical properties of cloaked nanosystems.
Keywords:
bio-stealthbiomedical applicationscell membraneslong circulation timesynthetic nanosystem

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  • Discussion of *in vivo* performance and biomedical applications.

    • Main Results:

    • Cell membrane cloaking imparts natural cell membrane properties to synthetic nanocarriers.
    • Cloaked nanoparticles exhibit enhanced circulation time and reduced immune recognition.
    • Inherited biological functions include immunosuppressive capabilities and targeted recognition.

    Conclusions:

    • Cell membrane cloaking is a promising strategy to overcome immune barriers in drug delivery.
    • This biomimetic system integrates synthetic nanomaterials with natural cell membrane functions.
    • Cell membrane-covered nanosystems hold significant potential for future biomedical applications.