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Related Concept Videos

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Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Related Experiment Video

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing for Alzheimer's Disease Based on Protein-Protein Interaction Network.

Negar Sadat Soleimani Zakeri1, Saeid Pashazadeh2, Habib MotieGhader3

  • 1Department of Computer Engineering, Faculty of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran.

Biomed Research International
|October 25, 2021
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Summary

This study identifies key gene complexes in Alzheimer's disease (AD) and proposes novel drugs, like raloxifene and gentian violet, for its treatment. The findings offer new avenues for AD prevention and therapeutic strategies.

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Area of Science:

  • Neurodegenerative Disorders
  • Genomics
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing global impact.
  • Effective prevention and treatment strategies for AD are crucial due to its escalating prevalence.

Purpose of the Study:

  • To identify significant gene complexes implicated in Alzheimer's disease.
  • To propose novel therapeutic drug candidates for AD treatment and prevention.

Main Methods:

  • Utilized protein-protein interaction (PPI) networks to extract five functional gene complexes.
  • Performed enrichment analysis to identify key biological processes and pathways.
  • Employed Connectivity Map (CMAP) analysis for drug validation and identified potential new drugs, including raloxifene and gentian violet.

Main Results:

  • Successfully extracted five functionally interconnected gene complexes from the PPI network.
  • Identified and validated potential novel drug candidates for AD, including raloxifene and gentian violet.
  • Constructed networks illustrating gene complexes, their target drugs, and target microRNAs (miRNAs).

Conclusions:

  • The proposed method accurately identifies potential therapeutic targets and drugs for Alzheimer's disease.
  • Raloxifene and gentian violet represent promising novel therapeutic agents for AD that warrant further experimental investigation.
  • The study also identified potential miRNA targets for AD, offering additional research directions.