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Nonuremic Calciphylaxis Associated With Hypercalcemia and Rheumatologic Diseases
Athip Vatanapradith1, Ashwini Pujari1, Phani Morisetti2
1Department of Internal Medicine, Louisiana State University Health Science Center, Shreveport, Louisiana.
Kidney Medicine
|October 25, 2021
Summary
Calciphylaxis, a severe vascular condition, is increasingly seen beyond dialysis patients, affecting those with chronic kidney disease (CKD) and even normal kidney function. Early diagnosis and intervention are crucial due to its high mortality risk.
Area of Science:
- Nephrology
- Dermatology
- Vascular Biology
Background:
- Calcific uremic arteriolopathy (calciphylaxis) traditionally affected dialysis patients.
- Recent observations show calciphylaxis in kidney transplant recipients, advanced CKD patients not on dialysis, and individuals with preserved kidney function.
Observation:
- A case study details a patient with CKD stage 3b and hypercalcemia presenting with calciphylaxis.
- Skin biopsy confirmed features highly specific for calciphylaxis.
Findings:
- Calciphylaxis presents a significant morbidity and mortality risk.
- Prompt cessation of causative agents or treatment of underlying causes is essential.
Implications:
- This case highlights the need to consider calciphylaxis in non-uremic patients with necrotic skin lesions.
- Expanded differential diagnosis, risk assessment, and early imaging/biopsy are recommended for timely management.
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