Related Experiment Video

Updated: Oct 15, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

523

Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19

Zahra Elyaspour1, Mohammad Javad Zibaeenezhad1, Mahboobeh Razmkhah2

  • 148435Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|October 25, 2021
PubMed

Insights

COVID-19 severely impacts endothelial cells, causing vascular injury and thrombosis. Understanding these effects is crucial for developing therapies and reducing mortality from this systemic vascular disease.

Area of Science:

  • Cardiovascular Biology
  • Infectious Diseases
  • Hematology

Background:

  • COVID-19, caused by SARS-CoV-2, significantly affects endothelial cells, the lining of blood vessels.
  • Endothelial dysfunction is linked to vascular injury, coagulopathies, and thrombotic events, contributing to severe COVID-19 outcomes.
  • The precise origin of these vascular complications—direct viral effect versus cytokine storm—remains under investigation.

Purpose of the Study:

  • To explore the impact of COVID-19 on endothelial function.
  • To discuss the mechanisms leading to thrombosis in COVID-19 patients.
  • To review relevant biomarkers, clinical manifestations, and potential therapeutic strategies.

Main Methods:

  • Review of current scientific literature on COVID-19 and endothelial function.
  • Analysis of studies investigating SARS-CoV-2 interactions with endothelial cells.
  • Synthesis of data on laboratory findings and clinical presentations related to COVID-19-induced vascular disease.

Main Results:

  • SARS-CoV-2 directly targets endothelial cells, leading to widespread vascular damage.
  • Endothelial dysfunction correlates with disease severity and thrombotic complications.
  • Altered plasma biomarker levels reflect endothelial injury and systemic inflammation.

Conclusions:

  • COVID-19 should be recognized as a systemic vascular disease, not solely a respiratory illness.
  • Therapeutic strategies targeting endothelial integrity and function are promising.
  • Further research into the vascular aspects of COVID-19 is essential for improving patient outcomes and reducing mortality.

Keywords:
COVID19endothelial dysfunctionthrombosis

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