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Low Mean Nocturnal Baseline Impedance is Associated With a Pathological Acid Exposure Time in Children

Yolainis Rosado-Arias1, Erick Manuel Toro-Monjaraz, Roberto Cervantes-Bustamante

  • 1Departement of Gastroenterology and Nutrition Department, at Instituto Nacional de Pediatria, Mexico, Mexico.

Journal of Pediatric Gastroenterology and Nutrition
|October 25, 2021
PubMed

Insights

Children with pathological acid exposure time (AET) have lower baseline impedance (BI) and mean nocturnal baseline impedance (MNBI) values. These impedance measurements are valuable for assessing mucosal integrity in pediatric GERD evaluations.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Physiology
  • Diagnostic Medicine

Background:

  • Baseline impedance (BI) and mean nocturnal baseline impedance (MNBI) are indicators of mucosal integrity.
  • Pathologic acid exposure time (AET) is a key factor in gastroesophageal reflux disease (GERD).
  • Understanding the relationship between impedance measures and AET in children is crucial for accurate diagnosis.

Purpose of the Study:

  • To investigate the association between BI and MNBI with AET in pediatric patients.
  • To determine if impedance measurements can serve as reliable markers for mucosal integrity in children with suspected GERD.

Main Methods:

  • A retrospective study of children (≤18 years) undergoing endoscopy and pH-impedance monitoring (pH-MII).
  • Esophagitis grading using the Los Angeles classification.
  • Pathological AET defined by age-specific thresholds (≥5% for >1 year, ≥10% for ≤1 year).
  • BI and MNBI measurements were taken and averaged for analysis.

Main Results:

  • 25% of the 68 included patients had pathological AET.
  • MNBI was significantly higher than BI in channels 5 and 6.
  • Lower BI and MNBI values were observed in patients with pathological AET compared to those with normal AET.

Conclusions:

  • Children with pathological AET exhibit lower impedance values.
  • BI and MNBI measurements are recommended for routine pH-MII assessments in pediatric GERD evaluations.
Abstract

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