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Myelin-associated oligodendrocyte basic protein rs616147 polymorphism as a risk factor for Parkinson's disease

Vasileios Siokas1, Athina-Maria Aloizou1, Ioannis Liampas1

  • 1Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, Larissa, Greece.

Acta Neurologica Scandinavica
|October 25, 2021
PubMed
Abstract

Insights

The myelin-associated oligodendrocyte basic protein (MOBP) rs616147 genetic variant is associated with a reduced risk of Parkinson's disease (PD). This finding suggests a potential genetic link between PD and other neurodegenerative disorders like ALS.

Area of Science:

  • Neurogenetics
  • Neurodegenerative Diseases
  • Molecular Biology

Background:

  • The rs616147 polymorphism in the myelin-associated oligodendrocyte basic protein (MOBP) gene has been linked to amyotrophic lateral sclerosis (ALS).
  • Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) share etiological, pathophysiological, and genetic similarities.
  • The role of the MOBP rs616147 polymorphism in Parkinson's disease (PD) risk remains largely unexplored.

Purpose of the Study:

  • To investigate the association between the MOBP rs616147 polymorphism and the risk of developing Parkinson's disease (PD).

Main Methods:

  • A case-control study was conducted with 358 PD patients and 358 controls from Greece.
  • Participants were genotyped for the MOBP rs616147 polymorphism.
  • Alzheimer's disease (AD) patients (n=327) were also genotyped for MOBP rs616147 to validate findings against controls.

Main Results:

  • Univariate analysis revealed a significant association between the MOBP rs616147 polymorphism and PD risk across dominant, overdominant, and codominant inheritance models.
  • Specifically, the rs616147 polymorphism showed a protective effect against PD.
  • No significant association was found between the MOBP rs616147 polymorphism and Alzheimer's disease (AD) risk.

Conclusions:

  • The study provides preliminary evidence suggesting that the MOBP rs616147 genetic variant is associated with Parkinson's disease (PD).
  • This finding may indicate shared genetic factors between PD and other neurodegenerative conditions like ALS.
Keywords:
Alzheimer's diseaseMOBPParkinson's diseasegeneticsmyelin-associated oligodendrocyte basic proteinrs616147single nucleotide polymorphism

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