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Updated: Oct 15, 2025

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Recent Advances in Small Molecule-Based Intracellular pH Probes
Pankaj E Hande1, Yogesh G Shelke2, Anindya Datta1
1Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Abstract:
Intracellular pH plays an important role in many biological and pathological processes. Small-molecule based pH probes are found to be the most effective for pH sensing because of ease of preparation, high sensitivity, and quick response. They have many advantages such as small perturbation to the functions of the target, functional adaptability, cellular component-specific localization, etc. The present review highlights the flurry of recent activity in the development of such probes. The probes are categorized based on the type of fluorophore used like quinoline, coumarin, BODIPY, rhodamine, indolium, naphthalimide, etc., and their analytical performance is discussed.
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