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COVID-19 Vaccinations: A Comprehensive Review of Their Safety and Efficacy in Special Populations
Zhipeng Yan1, Ming Yang2, Ching-Lung Lai1
1Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Abstract:
COVID-19 has been spreading worldwide since late 2019. There is no definitive cure to date. Global vaccination programs are urgently required to confer herd immunity, reducing the incidence of COVID-19 infections and associated morbidity and mortality. However, a significant proportion of special populations are hesitant to receive vaccination due to their special conditions, namely, age (pediatrics and geriatrics), immunocompromised state, autoimmune diseases, chronic cardiovascular and pulmonary conditions, active or treated cancers, and pregnancy. This review aims to evaluate the existing evidence of COVID-19 vaccinations on these special populations and to provide clues to guide vaccination decision making to balance the benefits and risks of vaccinations.
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