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Related Experiment Video

Updated: Oct 15, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Recent Issues in Varicella-Zoster Virus Latency.

Peter G E Kennedy¹, Trine H Mogensen^2,3, Randall J Cohrs⁴

¹Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G61 1QH, UK.

|October 26, 2021

Summary

Varicella-zoster virus (VZV) latency involves restricted gene transcription, including VZV gene 63 and a novel VLT transcript. Epigenetic regulation and host immunity influence VZV reactivation syndromes.

Keywords:

epigenetics gene expression immunity latency neuron reactivation varicella-zoster virus

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Published on: January 23, 2014

Area of Science:

Virology
Neuroscience
Immunology

Background:

Varicella-zoster virus (VZV) causes chickenpox and shingles after latency in neurons.
Understanding VZV latency is crucial for managing reactivation syndromes.

Purpose of the Study:

To review recent advances in alphaherpesvirus latency, focusing on VZV ganglionic latency.
To explore viral gene transcription, epigenetic regulation, and immunological aspects of VZV latency.

Main Methods:

Review of recent literature on VZV latency.
Analysis of viral gene transcription during latency.
Investigation of epigenetic mechanisms regulating VZV gene expression.
Examination of host immunity's role in VZV reactivation.

Main Results:

VZV gene transcription during latency is highly restricted.
Key transcripts include VZV gene 63 and a novel VZV transcript (VLT).
Epigenetic regulation plays a significant role in VZV gene transcription.
Inborn errors in host immunity can predispose individuals to VZV reactivation.

Conclusions:

Recent research has clarified the restricted nature of VZV gene transcription during latency.
Epigenetic mechanisms and host immunity are critical factors in VZV latency and reactivation.
Further research into these areas will advance understanding and management of VZV-associated diseases.