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Updated: Oct 15, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
High platelet-lymphocyte ratio is a risk factor for 30-day mortality in in-hospital cardiac arrest patients: a
Lihong Huang1, Jingjing Peng1, Xuefeng Wang1
1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Objectives:
This study explored the association of early dynamic changes in inflammatory markers with 30-day mortality in in-hospital cardiac arrest (IHCA) patients.
Methods:
This study retrospectively enrolled 85 IHCA patients. The outcome was 30-day mortality. A linear mixed model was used to analyze the dynamic changes in laboratory indicators within 72 h after recovery of spontaneous circulation(ROSC).
Results:
Within 72 h after ROSC, the absolute monocyte count (AMC) showed no significant change trend, and the absolute lymphocyte count (ALC) showed an overall upward trend, while the absolute neutral count (ANC), white blood cell (WBC) count, platelet (PLT) count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) showed overall downward trends. Cox multivariate analysis showed that the Charlson comorbidity index (CCI) (HR = 2.37, 95%CI (1.08, 5.17)), Acute Physiology and Chronic Health Evaluation II (APACHE II) score (HR = 2.55, 95% CI (1.00, 6.50)), abnormal creatinine level before IHCA (HR = 3.42, 95% CI (1.44, 8.10)) and PLR within 72 h after ROSC (HR = 2.99, 95% CI (1.44, 6.21)) were independent risk factors for 30-day mortality.
Conclusions:
The PLR can be used as a predictor of 30-day mortality in IHCA patients.
