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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Comparison of causative microorganisms of posttraumatic endophthalmitis with and without retained intraocular foreign
Yao Yang1, Feng Mei1, Jiaqi Lin1
1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, 510060, China.
Background:
The goals of this work were to report the demographic characteristics of patients with clinically diagnosed endophthalmitis with or without intraocular foreign bodies (IOFBs) and to analyze the causative microorganisms.
Methods:
A retrospective analysis was conducted on 1257 patients with clinically diagnosed posttraumatic endophthalmitis who were admitted to Zhongshan Ophthalmic Center between January 1, 2013, and August 31, 2020.
Results:
Of the 1257 patients with clinically diagnosed posttraumatic endophthalmitis, 452 (36.0%) patients had IOFBs. Male dominance was more common among the patients with IOFBs than the patients without IOFBs. The average age of the patients with IOFBs was older than that of the patients without IOFBs. The most common microbial pathogens in these two groups were Gram-positive cocci and Gram-negative bacilli. Gram-positive bacilli were more common in the patients with IOFBs than in those without IOFBs (17.9 vs. 9.4%), and Bacillus spp. accounted for 12.6 and 5.5%, respectively. Fungi were less abundant in the patients with IOFBs than in those without IOFBs (8.0 vs. 15.6%).
Conclusions:
Patients with IOFBs were mostly male and older than those without IOFBs. Gram-positive bacilli were more common and fungi were less common in patients with IOFBs than in those without IOFBs.
Insights
This study found that patients with posttraumatic endophthalmitis and intraocular foreign bodies (IOFBs) were older males. Gram-positive bacilli were more prevalent, while fungi were less common in patients with IOFBs.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Posttraumatic endophthalmitis is a severe ocular infection often associated with intraocular foreign bodies (IOFBs).
- Understanding the demographic and microbial profiles of these patients is crucial for effective management.
Purpose of the Study:
- To characterize the demographic features of patients with clinically diagnosed posttraumatic endophthalmitis.
- To identify and analyze the causative microorganisms in patients with and without IOFBs.
Main Methods:
- Retrospective analysis of 1257 patients with posttraumatic endophthalmitis.
- Data collected from Zhongshan Ophthalmic Center between January 2013 and August 2020.
- Comparison of demographic and microbial data between patients with and without IOFBs.
Main Results:
- 452 (36.0%) patients had IOFBs.
- Patients with IOFBs were predominantly male and older compared to those without IOFBs.
- Gram-positive cocci and Gram-negative bacilli were common pathogens. Gram-positive bacilli (including Bacillus spp.) were more frequent in the IOFB group (17.9% vs. 9.4%), while fungi were less common (8.0% vs. 15.6%).
Conclusions:
- Intraocular foreign bodies in endophthalmitis are associated with older male patients.
- The microbial spectrum differs, with a higher prevalence of Gram-positive bacilli and a lower prevalence of fungi in patients with IOFBs.
