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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Dysregulation of complement system in HELLP syndrome
Shi Chen1, Zheng Li1, Yingdong He1
1Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, P.R. China.
Objective:
To investigate the expression of complement system's activation factors in patients with HELLP syndrome.
Methods:
A case-control study was performed. Sixteen HELLP syndrome patients, 32 severe preeclampsia patients, and 48 normal pregnancy women were involved in this studyELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, sC5b-9, s-Endoglin, and sflt-1 in the plasma.
Results:
The levels of C5a (P < 0.01) and sC5b-9 (P = 0.014) in HELLP syndrome were higher than those in severe preeclampsia patients.
Conclusions:
The abnormal activation of the complement system is more significant in the pathogenesis of HELLP syndrome than in severe preeclampsia.
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