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The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study

Michael S Tanner1, Deborah De Guingand1, Maya Reddy1,2

  • 1Department of Obstetrics & Gynaecology, Monash University, Clayton, Australia.

Hypertension in Pregnancy
|October 26, 2021
PubMed

Objective:To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia.Methods: A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes.Results:We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications.Conclusion: Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.

Keywords:
Preeclampsiaangiogeniccomorbiditiescomplicationshypertension

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