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Genistein: A Potent Anti-Breast Cancer Agent

Smitha S Bhat1, Shashanka K Prasad1, Chandan Shivamallu1

  • 1Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India.

Current Issues in Molecular Biology
|October 26, 2021
PubMed

Insights

Genistein, a soybean isoflavonoid, exhibits anti-cancer properties by influencing multiple cell signaling pathways. Its effectiveness in cancer treatment is dependent on dosage, timing, and individual patient factors.

Area of Science:

  • Phytochemistry
  • Molecular Biology
  • Oncology

Background:

  • Genistein is a prominent isoflavonoid found abundantly in soybeans.
  • It possesses diverse bioactive properties, making it a subject of intense research for its potential anti-cancer effects.

Purpose of the Study:

  • To investigate the multifaceted mechanisms underlying genistein's anti-cancer activity.
  • To explore the signaling pathways modulated by genistein in controlling cancer cell proliferation.

Main Methods:

  • Review of existing scientific literature on genistein's anti-cancer mechanisms.
  • Analysis of pathways including cell proliferation, tyrosine kinases, Hedgehog-Gli1 signaling, epigenetics, cell cycle, and Akt/MEK pathways.

Main Results:

  • Genistein's anti-cancer effects are mediated through various pathways, including modulation of cell proliferation and signaling cascades.
  • Observed activities are contingent upon specific timeframes and dosages.
  • Genistein's efficacy varies in women, influenced by physiological states like menopausal status.

Conclusions:

  • Genistein demonstrates significant potential as an anti-cancer agent through diverse molecular mechanisms.
  • Further research is warranted to optimize its therapeutic application, considering time, dose, and patient-specific factors.
Keywords:
apoptosisbreast cancercell cycleestrogen receptorgenistein

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